Functional reconstitution of the Mycobacterium tuberculosis long‐chain acyl‐CoA carboxylase from multiple acyl‐CoA subunits
نویسندگان
چکیده
منابع مشابه
Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
Prokaryotic ubiquitin-like protein (Pup) is a post-translational modifier that attaches to more than 50 proteins in Mycobacteria. Proteasome accessory factor A (PafA) is responsible for Pup conjugation to substrates, but the manner in which proteins are selected for pupylation is unknown. To address this issue, we reconstituted the pupylation of model Mycobacterium proteasome substrates in Esch...
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15 صفحه اولCrystal structure of the essential biotin‐dependent carboxylase AccA3 from Mycobacterium tuberculosis
Biotin-dependent acetyl-CoA carboxylases catalyze the committed step in type II fatty acid biosynthesis, the main route for production of membrane phospholipids in bacteria, and are considered a key target for antibacterial drug discovery. Here we describe the first structure of AccA3, an essential component of the acetyl-CoA carboxylase system in Mycobacterium tuberculosis (MTb). The structure...
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ژورنال
عنوان ژورنال: The FEBS Journal
سال: 2017
ISSN: 1742-464X,1742-4658
DOI: 10.1111/febs.14046